Synonyms: Anastrozole; arimidex; anti-estrogen steroid
Molecular formula: C17H19N5
Molecular weight: 293.37
CAS NO: 120511-73-1
Appearance: an off-white color crystalline powder
Use: It can be used to the treatment of Breast cancer
Arimidex (generic name is anastrozole) is a newer drug developed
for the treatment of advanced breast cancer in women. It is
manufactured by Zenica Pharmaceuticals and was approved for use in
the United States at the end of December 1995. Specifically,
Arimidex is the first in a new class of third-generation selective
oral aromatase inhibitors.
It acts by blocking the enzyme aromatase, subsequently blocking the
production of estrogen. Since many forms of breast cancer cells are
stimulated by estrogen, it is hoped that by reducing amounts of
estrogen in the body the progression of such a disease can be
halted. This is the basic premise behind Nolvadex, except this drug
blocks the action and not production of estrogen.
The effects of Arimidex can be quite dramatic to say the least. A
daily dose of one tablet (1 mg) can produce estrogen suppression
greater than 80 % in treated patients. With the powerful effect
this drug has on hormone levels, it is only to be used (clinically)
by post-menopausal women whose disease has progressed following
treatment with Nolvadex (tamoxifen citrate). Side effects like hot
flushes and hair thinning can be present, and would no doubt be
much more severe in pre-menopausal patients.
There are some concerns with using an aromatase inhibitor such as
this during prolonged steroid treatment however. While it will
effectively reduce estrogenic side effects, it will also block the
beneficial properties of estrogen from becoming apparent (namely
its effect on cholesterol values). Studies have clearly shown that
when an aromatase inhibitor is used in conjunction with a steroid
such as testosterone, suppression of HDL (good) cholesterol becomes
much more pronounced.
Apparently estrogen plays a role in minimizing the negative impact
of steroid use. Since the estrogen receptor antagonist Nolvadex is
shown not to display an anti-estrogenic effect on cholesterol
values, it is certainly the preferred from of estrogen maintenance
for those concerned with cardiovascular health.
Most commonly called Arimidex, this substance is a true aromatase
inhibitor which works by blocking the aromatase enzyme in the body,
thus limiting the amount of estrogen buildup that takes place. This
compound has obvious benefits to bodybuilders who use aromatizing
steroids such as testosterone. These individuals might face
estrogen related side effects such as water bloat and "gyno", but
by taking GP Anastrozole while on cycle, the chance of any of these
sides are greatly reduced.
In studies that have been done, Arimidex has been shown to reduce
estrogen in the body by roughly 50%. This is a good balance for
bodybuilders , because some estrogen is needed in order for the
full anabolic benefits of the steroids being taken to be achieved.
These results are typically the same with a dosage of .5 mg a day
as they are with a dosage of 1 mg a day, meaning that in most
cases, a half tablet a day will be sufficient for estrogen control
Typically, bodybuilders using GP Anastrozole will begin taking it
the day they start their cycle, and will run it throughout the
duration of steroid administration. It is also important to point
out GP Anastrozole’s ability to increase testosterone in the body.
Some studies have shown that natural testosterone levels have
increases as much as 60% after the use of this substance for 7
days. Because of this, bodybuilders find this drug extremely
effective during PCT where as they are trying to elevate natural
levels as much as possible in order to avoid a post cycle "crash".
It is generally recommended that upon discontinuance of steroid
use, that one continue to run GP Anastrozole throughout the
duration of their PCT regime. (4-6) weeks.